Adhesins as Targets for Vaccine Development
نویسندگان
چکیده
منابع مشابه
Adhesins as targets for vaccine development.
Blocking the primary stages of infection, namely bacterial attachment to host cell receptors and colonization of the mucosal surface, may be the most effective strategy to prevent bacterial infections. Bacterial attachment usually involves an interaction between a bacterial surface protein called an adhesin and the host cell receptor. Recent preclinical vaccine studies with the FimH adhesin (de...
متن کاملComposite Sequence–Structure Stability Models as Screening Tools for Identifying Vulnerable Targets for HIV Drug and Vaccine Development
Rapid evolution and high sequence diversity enable Human Immunodeficiency Virus (HIV) populations to acquire mutations to escape antiretroviral drugs and host immune responses, and thus are major obstacles for the control of the pandemic. One strategy to overcome this problem is to focus drugs and vaccines on regions of the viral genome in which mutations are likely to cripple function through ...
متن کاملTick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets
Tick-pathogen-host interactions have been closely studied to understand the molecular mechanisms of pathogen transmission for tick-borne diseases, including Lyme disease, babesiosis, spotted fever diseases, and Tick-borne encephalitis, among others. Such studies have yielded insights into disease processes and have identified promising candidates for vaccines against tick-borne diseases (Dai et...
متن کاملIAP proteins as targets for drug development in oncology
The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as ...
متن کاملHistamine Receptors as Potential Therapeutic Targets for Cancer Drug Development
Although research over the last decade has led to new and improved therapies for a variety of different diseases, anticancer drug therapy continues to have undesirable outcomes, including both poor response and severe toxicity. In addition to the critical need to discover new drugs, it is important to optimize existing therapies in order to minimize adverse reactions and maximize efficacy. In t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 1999
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid0503.990310